Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001)

Published on Nov 12, 2013in British Journal of Cancer5.791
· DOI :10.1038/BJC.2013.620
S. Nicholson1
Estimated H-index: 1
(Imperial College Healthcare),
Emma Hall57
Estimated H-index: 57
(ICR: Institute of Cancer Research)
+ 10 AuthorsAmit Bahl24
Estimated H-index: 24
Sources
Abstract
Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001)
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UNLABELLED: What's known on the subject? and What does the study add? Metastatic or locally advanced squamous cell carcinoma of the penis (SCCP) is generally incurable, but it can be palliated with systemic chemotherapy. Two retrospective studies, involving <10 patients each, showed that cisplatin plus continuous infusion of 5-fluorouracil (5-FU) may be effective and well tolerated. Cisplatin, methotrexate and bleomycin, cisplatin and irinotecan and taxanes can also play an important role for pa...
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4639 Background: Treatment of patients (pts) with advanced penile SCC is very often unsuccessful. Single agents or combination therapies (Rx) combined with surgery achieved unsatisfactory results. We evaluated TPF in either neoadjuvant (NA), adjuvant (A) or metastatic (M) setting in a single-center pilot trial. Methods: 3-4 courses of paclitaxel 120 mg/m2 d1 or docetaxel 75 mg/m2 d1 + cisplatin 75 mg/m2 d1 + 5-fluorouracil (5FU) 96 hrs continuous infusion 750 mg/m2 from d1, q3wks were provided. ...
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Purpose Men with penile squamous cell carcinoma and regional lymph node involvement have a low probability of survival with lymphadenectomy alone. A multimodal approach to treatment is desirable for such patients. We performed a phase II study of neoadjuvant chemotherapy with the objective of determining the response rate, time to progression (TTP), and overall survival (OS) among patients with bulky adenopathy. Patients and Methods Eligible patients had stage N2 or N3 (stage III or stage IV) pe...
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Abstract Background Chemotherapy is emerging in the management of advanced penile cancer. Objective To evaluate the therapeutic activity of taxanes (T) in combination with cisplatin-fluorouracil (PF) for salvage of primarily unresectable or relapsed nodal metastases from squamous cell carcinoma (SCC) of the penis. Design, setting, and participants Six consecutive patients were treated at Istituto Nazionale Tumori (INT), Milano, with neoadjuvant paclitaxel, cisplatin, and 5-fluorouracil (TPF) for...
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Purpose: Combination chemotherapy for advanced penile cancer can produce partial response rates of up to 64%. Complete responses are rare, suggesting a need for adjunct therapies to facilitate cure. We evaluated patients with metastases who underwent surgical consolidation after responding to chemotherapy.Materials and Methods: We reviewed the records of 59 patients with advanced penile carcinoma treated from 1985 to 2000 and identified 10 treated with surgical consolidation after demonstrating ...
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Penile cancer is rare in Western countries. High-risk patients are considered for prophylactic inguinal lymphadenectomy. For advanced disease, a triplet drug regimen consisting of bleomycin, methotrexate, and cisplatin is the most active combination tested so far. A 62-year-old man with penile cancer underwent partial penile amputation but presented 10 months later with inguinal nodal metastasis. He received three cycles of paclitaxel/carboplatin with marked clinical and radiologic (computed tom...
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Penile squamous cell carcinoma (PSCC) is a rare malignancy with poor survival after standard treatment. Although genomic alterations of PSCC have been characterized in several latest studies, the association between the formation of somatic landscape and regional lymph node metastasis (LNM), an important predictor for patient survival, has not been comprehensively investigated. Here, we collected formalin-fixed paraffin-embedded tumor tissue and matched normal samples of 32 PSCC patients, includ...
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