Influence of the partial volume correction method on (18)F-fluorodeoxyglucose brain kinetic modelling from dynamic PET images reconstructed with resolution model based OSEM.

Published on Oct 21, 2013in Physics in Medicine and Biology2.883
· DOI :10.1088/0031-9155/58/20/7081
Spencer L. Bowen11
Estimated H-index: 11
Christian Michel20
Estimated H-index: 20
+ 2 AuthorsCiprian Catana40
Estimated H-index: 40
Kinetic parameters estimated from dynamic 18F-fluorodeoxyglucose (18F-FDG) PET acquisitions have been used frequently to assess brain function in humans. Neglecting partial volume correction (PVC) for a dynamic series has been shown to produce significant bias in model estimates. Accurate PVC requires a space-variant model describing the reconstructed image spatial point spread function (PSF) that accounts for resolution limitations, including non-uniformities across the field of view due to the parallax effect. For ordered subsets expectation maximization (OSEM), image resolution convergence is local and influenced significantly by the number of iterations, the count density, and background-to-target ratio. As both count density and background-to-target values for a brain structure can change during a dynamic scan, the local image resolution may also concurrently vary. When PVC is applied post-reconstruction the kinetic parameter estimates may be biased when neglecting the frame-dependent resolution. We explored the influence of the PVC method and implementation on kinetic parameters estimated by fitting 18F-FDG dynamic data acquired on a dedicated brain PET scanner and reconstructed with and without PSF modelling in the OSEM algorithm. The performance of several PVC algorithms was quantified with a phantom experiment, an anthropomorphic Monte Carlo simulation, and a patient scan. Using the last frame reconstructed image only for regional spread function (RSF) generation, as opposed to computing RSFs for each frame independently, and applying perturbation geometric transfer matrix PVC with PSF based OSEM produced the lowest magnitude bias kinetic parameter estimates in most instances, although at the cost of increased noise compared to the PVC methods utilizing conventional OSEM. Use of the last frame RSFs for PVC with no PSF modelling in the OSEM algorithm produced the lowest bias in cerebral metabolic rate of glucose estimates, although by less than 5% in most cases compared to the other PVC methods. The results indicate that the PVC implementation and choice of PSF modelling in the reconstruction can significantly impact model parameters.
📖 Papers frequently viewed together
539 Citations
146 Citations
26 Citations
#1Arman Rahmim (Johns Hopkins University)H-Index: 35
#2Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
Last. Vesna Sossi (UBC: University of British Columbia)H-Index: 56
view all 3 authors...
In this paper, the authors review the field of resolution modeling in positron emission tomography (PET) image reconstruction, also referred to as point-spread-function modeling. The review includes theoretical analysis of the resolution modeling framework as well as an overview of various approaches in the literature. It also discusses potential advantages gained via this approach, as discussed with reference to various metrics and tasks, including lesion detection observer studies. Furthermore...
240 CitationsSource
#1Kjell Erlandsson (UCL: University College London)H-Index: 27
#2Irène Buvat (CNRS: Centre national de la recherche scientifique)H-Index: 46
Last. Brian Hutton (UCL: University College London)H-Index: 66
view all 5 authors...
Accurate quantification in PET and SPECT requires correction for a number of physical factors, such as photon attenuation, Compton scattering and random coincidences (in PET). Another factor affecting quantification is the limited spatial resolution. While considerable effort has gone into development of routine correction techniques for the former factors, less attention has been paid to the latter. Spatial resolution-related effects, referred to as ‘partial volume effects’ (PVEs), depend not o...
539 CitationsSource
#1Mike Sattarivand (Sunnybrook Health Sciences Centre)H-Index: 3
#2Maggie Kusano (Sunnybrook Health Sciences Centre)H-Index: 3
Last. Curtis Caldwell (Sunnybrook Health Sciences Centre)H-Index: 1
view all 4 authors...
Limited spatial resolution of positron emission tomography (PET) often requires partial volume correction (PVC) to improve the accuracy of quantitative PET studies. Conventional region-based PVC methods use co-registered high resolution anatomical images (e.g. computed tomography (CT) or magnetic resonance images) to identify regions of interest. Spill-over between regions is accounted for by calculating regional spread functions (RSFs) in a geometric transfer matrix (GTM) framework. This paper ...
26 CitationsSource
#1Stephan Blinder (UBC: University of British Columbia)H-Index: 14
#2Katherine Dinelle (UBC: University of British Columbia)H-Index: 13
Last. Vesna Sossi (UBC: University of British Columbia)H-Index: 56
view all 3 authors...
Purpose: The Siemens ECAT high resolution research tomograph (HRRT) is a dedicated human brainPETcamera with a 6% absolute sensitivity and a (2.3 mm)3spatial resolution, improving to (1.8 mm)3 when point spread function (PSF) modeling algorithms are used. These values are very close to those of dedicated small animal PETcameras such as the Siemens microPET FOCUS 120 (F120). The larger axial and transaxial field of view of the HRRT compared to the F120 allows, in principle, for simultaneous imagi...
18 CitationsSource
#1Wencke Lehnert (USYD: University of Sydney)H-Index: 7
#2Marie-Claude Gregoire (ANSTO: Australian Nuclear Science and Technology Organisation)H-Index: 31
Last. Steven R. Meikle (USYD: University of Sydney)H-Index: 39
view all 4 authors...
Abstract Accurate quantification of PET imaging data is required for a useful interpretation of the measured radioactive tracer concentrations. The partial volume effect (PVE) describes signal dilution and mixing due to spatial resolution and sampling limitations, which introduces bias in quantitative results. In the present study we investigated the magnitude of PVE for volumes of interest (VOIs) in the rat brain and the effect of positron range. In simulated 11C-raclopride studies we examined ...
41 CitationsSource
#1Armin KolbH-Index: 14
#2Hans F. WehrlH-Index: 22
Last. Bernd J. PichlerH-Index: 64
view all 14 authors...
Objectives Technical performance evaluation of a human brain PET/MRI system. Methods The magnetic field compatible positron emission tomography (PET) insert is based on avalanche photodiode (APD) arrays coupled with lutetium oxyorthosilicate (LSO) crystals and slip-fits into a slightly modified clinical 3-T MRI system. The mutual interference between the two imaging techniques was minimised by the careful design of the hardware to maintain the quality of the B0 and B1 field homogeneity. Results ...
122 CitationsSource
#1Fotis A. Kotasidis (University of Manchester)H-Index: 13
#2Julian C. Matthews (University of Manchester)H-Index: 26
Last. Andrew J. Reader (Montreal Neurological Institute and Hospital)H-Index: 30
view all 8 authors...
Incorporation of a resolution model during statistical image reconstruction often produces images of improved resolution and signal-to-noise ratio. A novel and practical methodology to rapidly and accurately determine the overall emission and detection blurring component of the system matrix using a printed point source array within a custom-made Perspex phantom is presented. The array was scanned at different positions and orientations within the field of view (FOV) to examine the feasibility o...
41 CitationsSource
#1Matthew D. Walker (University of Manchester)H-Index: 13
#2M.-C. Asselin (University of Manchester)H-Index: 10
Last. Julian C. Matthews (University of Manchester)H-Index: 26
view all 7 authors...
Iterative image reconstruction methods such as ordered-subset expectation maximization (OSEM) are widely used in PET. Reconstructions via OSEM are however reported to be biased for low-count data. We investigated this and considered the impact for dynamic PET. Patient listmode data were acquired in [11C]DASB and [15O]H2O scans on the HRRT brain PET scanner. These data were subsampled to create many independent, low-count replicates. The data were reconstructed and the images from low-count data ...
89 CitationsSource
#1Ciprian Catana (Harvard University)H-Index: 40
#2Thomas BennerH-Index: 49
Last. A. Gregory SorensenH-Index: 82
view all 10 authors...
Head motion is difficult to avoid in long PET studies, degrading the image quality and offsetting the benefit of using a highresolution scanner. As a potential solution in an integrated MRPET scanner, the simultaneously acquired MRI data can be used for motion tracking. In this work, a novel algorithm for data processing and rigid-body motion correction (MC) for the MRIcompatible BrainPET prototype scanner is described, and proof-of-principle phantom and human studies are presented. Methods: To ...
151 CitationsSource
#1Christophe Cloquet (ULB: Université libre de Bruxelles)H-Index: 3
#2F C Sureau (Vrije Universiteit Brussel)H-Index: 1
Last. Serge Goldman (ULB: Université libre de Bruxelles)H-Index: 67
view all 6 authors...
Partial volume effect is an important source of bias in PET images that can be lowered by accounting for the point spread function (PSF) of the scanner. We measured such a PSF in various points of a clinical PET scanner and modelled it as a product of matrices acting in image space, taking the asymmetrical, shift-varying and non-Gaussian character of the PSF into account (AMP modelling), and we integrated this accurate image space modelling into a conventional list-mode OSEM algorithm (EM-AMP re...
49 CitationsSource
Cited By17
#1José Paredes-Pacheco (UMA: University of Málaga)H-Index: 5
#2Francisco Javier López-González (UMA: University of Málaga)H-Index: 3
Last. Pablo Aguiar (University of Santiago de Compostela)H-Index: 16
view all 8 authors...
PURPOSE SimPET ( is a free cloud-based platform for the generation of realistic brain Positron Emission Tomography (PET) data. In this work, we introduce the key features of the platform. In addition, we validate the platform by performing a comparison between simulated healthy brain FDG-PET images and real healthy subject data for three commercial scanners (GE Advance NXi, GE Discovery ST, and Siemens Biograph mCT). METHODS The platform provides a graphical user interface to a s...
#1Yudong Zhang (University of Leicester)H-Index: 73
#2Zhengchao Dong (Columbia University)H-Index: 28
Last. Juan Manuel Górriz (University of Cambridge)H-Index: 45
view all 12 authors...
Abstract Multimodal fusion in neuroimaging combines data from multiple imaging modalities to overcome the fundamental limitations of individual modalities. Neuroimaging fusion can achieve higher temporal and spatial resolution, enhance contrast, correct imaging distortions, and bridge physiological and cognitive information. In this study, we analyzed over 450 references from PubMed, Google Scholar, IEEE, ScienceDirect, Web of Science, and various sources published from 1978 to 2020. We provide ...
36 CitationsSource
#1Timo Grimmer (LMU: Ludwig Maximilian University of Munich)H-Index: 40
#3Janine Diehl-Schmid (LMU: Ludwig Maximilian University of Munich)H-Index: 40
Last. Behrooz H. Yousefi (LMU: Ludwig Maximilian University of Munich)H-Index: 20
view all 12 authors...
18F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[18F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image β-amyloid depositions (Aβ) in humans in-vivo that binds to Aβ with excellent affinity (Kd 0.7 ± 0.2) and high selectivity over tau and α-synuclein aggregates (Ki > 1000 nM). We aimed to characterize 18F-FIBT in a series of patients with different clinical-pathophysiological phenotypes and to compare its binding characteristics to ...
4 CitationsSource
#1David Izquierdo-Garcia (Harvard University)H-Index: 30
#2Mark C. Eldaief (Harvard University)H-Index: 13
Last. Ciprian Catana (Harvard University)H-Index: 40
view all 4 authors...
Recently, an exhaustive examination of 11 state-of-the-art MR-based attenuation correction (AC) concluded that there are currently a few methods showing similar results compared to the gold-standard, CT-based AC. While the study presented a thorough portfolio of metrics to quantify accuracy (bias) and quality, it lacked one of the most important metrics to quantify robustness that is critical for its clinical applicability: intrascanner reproducibility (repeatability). In this paper, we provide ...
6 CitationsSource
#1Matthijs C.F. Cysouw (VU: VU University Amsterdam)H-Index: 7
#2S. V. S. Golla (VU: VU University Amsterdam)H-Index: 1
Last. Ronald BoellaardH-Index: 83
view all 7 authors...
Partial-volume effects generally result in an underestimation of tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume correction (PVC) for accurate quantification. However, investigation of PVC in dynamic oncological PET studies to date is scarce. The aim of this study was to investigate PVC’s impact on tumor kinetic parameter estimation from dynamic PET-CT acquisitions and subsequent validation of simplified semi-quantitative metrics. Ten patients with EGFR-mutated non-...
5 CitationsSource
#1Kevin T. Chen (MIT: Massachusetts Institute of Technology)H-Index: 12
#2Stephanie Salcedo (Harvard University)H-Index: 8
Last. Ciprian Catana (Harvard University)H-Index: 40
view all 10 authors...
: A main advantage of PET is that it provides quantitative measures of the radiotracer concentration, but its accuracy is confounded by several factors, including attenuation, subject motion, and limited spatial resolution. Using the information from one simultaneously acquired morphological MR sequence with embedded navigators, we propose an efficient method called MR-assisted PET data optimization (MaPET) to perform attenuation correction (AC), motion correction, and anatomy-aided reconstructi...
8 CitationsSource
#1Kevin T. Chen (MIT: Massachusetts Institute of Technology)H-Index: 12
#2Stephanie Salcedo (Harvard University)H-Index: 8
Last. Ciprian Catana (Harvard University)H-Index: 40
view all 8 authors...
BACKGROUND: Subject motion in positron emission tomography (PET) studies leads to image blurring and artifacts; simultaneously acquired magnetic resonance imaging (MRI) data provides a means for motion correction (MC) in integrated PET/MRI scanners. PURPOSE: To assess the effect of realistic head motion and MR-based MC on static [18 F]-fluorodeoxyglucose (FDG) PET images in dementia patients. STUDY TYPE: Observational study. POPULATION: Thirty dementia subjects were recruited. FIELD STRENGTH/SEQ...
21 CitationsSource
#1Kjell Erlandsson (UCL: University College London)H-Index: 27
Spill over of data between different regions in a PET image is known as the “partial volume effect” (PVE) and leads to errors in the quantification of local tracer concentration. PVE can be a confounding factor in clinical studies if the effect changes over time or between subjects, and it is then important to correct for PVE. Such a correction procedure is known as “partial volume correction” (PVC). Since the PVE depends on the spatial resolution of the PET images, some degree of compensation c...
2 CitationsSource
#1Lisa Schütz (Leipzig University)H-Index: 1
#2Donald Lobsien (Leipzig University)H-Index: 18
Last. Henryk Barthel (Leipzig University)H-Index: 56
view all 19 authors...
Purpose Established Alzheimer’s disease (AD) biomarker concepts classify into amyloid pathology and neuronal injury biomarkers, while recent alternative concepts classify into diagnostic and progression AD biomarkers. However, combined amyloid positron emission tomography/magnetic resonance imaging (PET/MRI) offers the chance to obtain both biomarker category read-outs within one imaging session, with increased patient as well as referrer convenience. The aim of this pilot study was to investiga...
13 CitationsSource
#1Spencer L. BowenH-Index: 11
#2Niccolo FuinH-Index: 7
Last. Ciprian CatanaH-Index: 40
view all 4 authors...
: Attenuation correction for PET-MR systems continues to be a challenging problem, particularly for body regions outside the head. The simultaneous acquisition of transmission scan based μ-maps and MR images on integrated PET-MR systems may significantly increase the performance of and offer validation for new MR-based μ-map algorithms. For the Biograph mMR (Siemens Healthcare), however, use of conventional transmission schemes is not practical as the patient table and relatively small diameter ...
13 CitationsSource