Gastrointestinal stromal tumour and other mesenchymal tumours of the gastrointestinal tract: the role of immunohistochemistry in an evolving era of molecular diagnostics

Significant progress has been made in the molecular characterization of soft tissue tumours arising in the gastrointestinal tract, primarily with the identification of recurrent translocations, gene amplifications and mutations in different tumour types. Translational studies have resulted in the development of many diagnostically useful immunohistochemical markers that reflect these underlying genetic changes. In addition, expression of some...