Scaffolds for connective tissue regeneration

Background. – Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein that mediates cell–matrix interactions. In adults, its expression is mostly limited to tissue undergoing remodeling. During the development of Cyclosporin A (CsA)-induced gingival overgrowth (GO) a remodeling of the connective compartment occurs. By contrast, clinical trials showed that FK506 is not related to GO.SPARC expression and its involvement in GO is...