Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

Volume: 89, Issue: 10, Pages: 4544 - 4548
Published: May 15, 1992
Abstract
We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups) with HNE leads to the generation of HNE-protein adducts, which are converted to radioactive derivatives upon subsequent treatment with NaB[3H]H4. Amino acid analysis of the modified protein showed that the HNE treatment leads to the selective loss of...
Paper Details
Title
Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.
Published Date
May 15, 1992
Volume
89
Issue
10
Pages
4544 - 4548
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