Simultaneous Determination of pKa and Lipophilicity by Gradient RP HPLC
Abstract
High-performance methods of testing of drug candidates for properties of pharmacokinetics and pharmacodynamics importance, in particular lipophilicity and acidity, are necessary to overcome innovation stagnation in the pharmaceutical industry. Reversed-phase high-performance liquid chromatography (RP HPLC) might be a unique tool for the determination of both pKa and the apparent (pH-dependent) partition coefficient, applicable in high-throughput...
Paper Details
Title
Simultaneous Determination of pKa and Lipophilicity by Gradient RP HPLC
Published Date
Nov 25, 2005
Journal
Volume
78
Issue
1
Pages
239 - 249
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