Hyperforin and its analogues inhibit CYP3A4 enzyme activity
Abstract
Literature indicates that herb-drug interaction of St. John's wort is largely due to increased metabolism of the co-administered drugs that are the substrates of cytochrome P450 (CYP) 3A4 enzyme, alteration of the activity and/or expression of the enzyme. The major St. John's wort constituents, acylphloroglucinols, were evaluated for their effects on CYP3A4 enzyme activity to investigate their roles in herb-drug interaction. Hyperforin and four...
Paper Details
Title
Hyperforin and its analogues inhibit CYP3A4 enzyme activity
Published Date
Dec 1, 2006
Journal
Volume
67
Issue
23
Pages
2550 - 2560
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