Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle
Abstract
The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of...
Paper Details
Title
Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle
Published Date
Jun 15, 2012
Journal
Volume
86
Issue
12
Pages
7003 - 7007
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