Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion

To investigate the relation of expression transformation of claudin-1 with invasiveness and metastasis of gastric carcinoma.By using immunohistochemistry, expression of claudin-1 in mucosa and invasive front of 136 gastric adenocarcinoma cases and proliferative index (Ki-67) were detected and analyzed.In mucosa, the claudin-1 over-expression rate of mucinous adenocarcinomas (including signet-ring cell carcinomas) was the highest. It was...