Resolution of chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography using methylated β-cyclodextrins
Abstract
null null The correlation between the capacity factors of enantiomers of chiral barbiturates and the concentrations of β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin dissolved in the mobile phase was studied using LiChrosorb RP-18 as the stationary phase. Owing to the very strong adsorption of permethylated β-cyclodextrin on the ODS surface a chiral stationary phase is generated...
Paper Details
Title
Resolution of chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography using methylated β-cyclodextrins
Published Date
Jan 1, 1988
Journal
Volume
436
Issue
3
Pages
381 - 390
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