MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Abstract
Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) families. Both families of enzymes cleave aggrecan at specific sites within the aggrecan core protein. One cleavage site within the interglobular domain (IGD), between Glu373–374Ala and five additional...
Paper Details
Title
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Published Date
Mar 1, 2011
Journal
Volume
30
Issue
2
Pages
145 - 153
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