A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease
Abstract
Inducible nitric oxide synthase (iNOS) upregulation and consequent NO formation are well-recognized neuroinflammatory responses associated with Parkinson's disease (PD). These contribute to nitrosative protein modifications affecting neuronal injury and cell death. Indeed, a pathobiologic signature for PD is Lewy body formation containing misfolded and aggregated forms of alpha-synuclein (α-syn). Moreover, nitration of α-syn promotes protein...
Paper Details
Title
A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease
Published Date
Aug 1, 2012
Journal
Volume
523
Issue
2
Pages
167 - 173
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