High Sensitivity of Reverse-hybridization Methodology in the Detection of KRAS Mutations from Formalin-fixed Paraffin-embedded Colorectal Cancer Samples

Colorectal cancer is ranked the third most common cancer worldwide in terms of incidence and the second in terms of mortality. Recent advances in therapeutic approaches to colorectal cancer have identified a potential role of anti-epidermal growth factor receptor (EGFR) targeted therapies as adjuvant treatment in advanced disease. New evidences showed that patients harboring KRAS mutations on codons 12 and 13 are not responsive to anti-EGFR...