Targeting the Cancer-Stroma Interaction: A Potential Approach for Pancreatic Cancer Treatment
Abstract
Recent studies have demonstrated that the interaction between the cancer and the stroma, play a key role in the development of pancreatic cancer. The desmoplasia, which consists of fibroblasts, pancreatic stellate cells, lymphatic and vascular endothelial cells, immune cells, pathologic increased nerves, and the extracellular matrix (ECM), creates a complex tumor microenvironment that promotes pancreatic cancer development, invasion, metastasis,...
Paper Details
Title
Targeting the Cancer-Stroma Interaction: A Potential Approach for Pancreatic Cancer Treatment
Published Date
Apr 1, 2012
Volume
18
Issue
17
Pages
2404 - 2415
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