Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β
Abstract
Here we report the design, chemical and recombinant synthesis, and functional properties of a series of novel inhibitors of human mast cell tryptase β, a protease of considerable interest as a therapeutic target for the treatment of allergic asthma and inflammatory disorders. These inhibitors are derived from a linear variant of the cyclic cystine knot miniprotein MCoTI-II, originally isolated from the seeds of Momordica cochinchinensis. A...
Paper Details
Title
Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β
Published Date
Jan 1, 2010
Journal
Volume
395
Issue
1
Pages
167 - 175
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