Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
Abstract
Proteolysis of the cartilage proteoglycan aggrecan is a feature of arthritis. We present a method for analyzing aggrecanolysis in in vitro cultures of 3-week-old mouse femoral head cartilage based on traditional methods developed for large animal species. Investigators can choose either a simple analysis that detects several aggrecan fragments released into culture medium only or a more comprehensive study that detects all fragments present in...
Paper Details
Title
Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
Published Date
Mar 1, 2011
Journal
Volume
6
Issue
3
Pages
388 - 404
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