Inhibiting Metalloproteases with PD 166793 in Heart Failure: Impact on Cardiac Remodeling and Beyond

Volume: 26, Issue: 1, Pages: 24 - 37
Published: Jun 28, 2008
Abstract
Metalloproteinases (MMPs, also called matrixins) are extracellular proteolytic enzymes involved in the degradation of both matrix and nonmatrix proteins. Currently, 25 MMPs have been identified in humans, and the overexpression of one or more MMPs has been implicated in several pathologies, spanning from cancer to rheumathoid arthritis to cardiovascular disease. While research over the past 20 years has focused on understanding MMP biology and...
Paper Details
Title
Inhibiting Metalloproteases with PD 166793 in Heart Failure: Impact on Cardiac Remodeling and Beyond
Published Date
Jun 28, 2008
Volume
26
Issue
1
Pages
24 - 37
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