Attenuating effect of H⁺K⁺ATPase inhibitors on airway cough hypersensitivity induced by allergic airway inflammation in guinea‐pigs

Summary Background Gastrooesophageal reflux (GER) is a frequent cause of chronic cough. Several investigators have indicated that inhibitors of H + K + ATPase (proton pump inhibitors; PPIs) could relieve coughing via inhibition of acid reflux. However, we considered that PPIs might directly inhibit increased cough reflex sensitivity. Objective The present study was designed to examine whether PPIs directly inhibit antigen‐induced increase in...