Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Abstract
Vertebrates achieve internal homeostasis during infection or injury by balancing the activities of proinflammatory and anti-inflammatory pathways. Endotoxin (lipopolysaccharide), produced by all gram-negative bacteria, activates macrophages to release cytokines that are potentially lethal. The central nervous system regulates systemic inflammatory responses to endotoxin through humoral mechanisms. Activation of afferent vagus nerve fibres by...
Paper Details
Title
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Published Date
May 1, 2000
Journal
Volume
405
Issue
6785
Pages
458 - 462
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Notes
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