Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1
Abstract
The orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) is a potent regulator of cholesterol metabolism and bile acid homeostasis. Recently, LRH-1 has been shown to play an important role in intestinal inflammation and in the progression of estrogen receptor positive and negative breast cancers and pancreatic cancer. Structural studies have revealed that LRH-1 can bind phospholipids and the dietary phospholipid...
Paper Details
Title
Antiproliferation Activity of a Small Molecule Repressor of Liver Receptor Homolog 1
Published Date
Dec 3, 2014
Journal
Volume
87
Issue
2
Pages
296 - 304
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