Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis
Abstract
Systemic AL amyloidosis results from the aggregation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell clone in the bone marrow. AL is the most rapidly fatal of the systemic amyloidoses, as amyloid fibrils can rapidly accumulate in tissues including the heart, kidneys, autonomic or peripheral nervous systems, gastrointestinal tract, and liver. Chemotherapy is used to eradicate the cellular source of the...
Paper Details
Title
Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis
Published Date
Dec 15, 2011
Journal
Volume
118
Issue
25
Pages
6610 - 6617
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