The Effects of Diethylstilbestrol and Medroxyprogesterone Acetate on Kinetics and Production of Testosterone and Dihydrotestosterone in Patients with Prostatic Carcinoma

Abstract
Alterations in the metabolism of testosterone (T) and dihydrotestosterone (DHT) induced by diethylstilbestrol (DES) or medroxprogesterone acetate (MPA) could account for the beneficial therapeutic effect of these agents in prostatic carcinoma. To investigate this possibility we sutdied plasma kinetics of T and DHT in 17 elderly patients with prostatic carcinoma, before and after treatment with DES (1 or 5 mg/d) or MPA (10 or 30 mg/d) for 30...
Paper Details
Title
The Effects of Diethylstilbestrol and Medroxyprogesterone Acetate on Kinetics and Production of Testosterone and Dihydrotestosterone in Patients with Prostatic Carcinoma
Published Date
Dec 1, 1976
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