Elucidation of Molecular Events Leading to Neutrophil Apoptosis following Phagocytosis

Phagocytosis of complement-opsonized targets is a primary function of neutrophils at sites of inflammation, and the clearance of neutrophils that have phagocytosed microbes is important for the resolution of inflammation. Our previous work suggests that phagocytosis leads to rapid neutrophil apoptosis that is inhibited by antibody to the β2 integrin, Mac-1, and requires NADPH oxidase-derived reactive oxygen species (ROS) generated during...