Functions of BCL-XLat the Interface between Cell Death and Metabolism
Abstract
The BCL-2 homolog BCL-X L , one of the two protein products of BCL2L1 , has originally been characterized for its prominent prosurvival functions. Similar to BCL-2, BCL-X L binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the formation of lethal pores in the mitochondrial outer membrane, as well as to multiple BH3-only proteins, thus interrupting apical proapoptotic signals. In addition, BCL-X L has been suggested...
Paper Details
Title
Functions of BCL-XLat the Interface between Cell Death and Metabolism
Published Date
Jan 1, 2013
Volume
2013
Pages
1 - 10
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