Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase

Cell64.50
Volume: 104, Issue: 6, Pages: 901 - 912
Published: Mar 23, 2001
Abstract
Rifampicin (Rif) is one of the most potent and broad spectrum antibiotics against bacterial pathogens and is a key component of anti-tuberculosis therapy, stemming from its inhibition of the bacterial RNA polymerase (RNAP). We determined the crystal structure of Thermus aquaticus core RNAP complexed with Rif. The inhibitor binds in a pocket of the RNAP beta subunit deep within the DNA/RNA channel, but more than 12 A away from the active site....
Paper Details
Title
Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
Published Date
Mar 23, 2001
Journal
Volume
104
Issue
6
Pages
901 - 912
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