Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases

Volume: 37, Issue: 6, Pages: 441 - 448
Published: Jun 30, 2014
Abstract
Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes. These multiprotein complexes activate inflammatory caspases (i.e., caspase-1) which in turn catalyze the maturation of select pro-inflammatory cytokines, including interleukin (IL)-1 and IL-18....
Paper Details
Title
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases
Published Date
Jun 30, 2014
Volume
37
Issue
6
Pages
441 - 448
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