The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2
Abstract
Organisms have evolved sophisticated and redundant mechanisms to manage oxidative and electrophilic challenges that arise from internal metabolism or xenobiotic challenge for survival. NF-E2-related factor 2 (Nrf2) is a transcription factor that has evolved over millennia from primitive origins, with homologues traceable back to invertebrate Caenorhabditis and Drosophila species. The ancestry of Nrf2 clearly has deep-seated roots in...
Paper Details
Title
The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2
Published Date
Apr 1, 2010
Volume
244
Issue
1
Pages
4 - 15
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