Neutrophils, IL-1β, and gout: is there a link?
Abstract
Gout is a prototype crystal-induced inflammatory disorder, characterized by neutrophil infiltration into inflamed joints. The identification of the role of NLRP3 inflammasome in the recognition of monosodium urate crystals and the subsequent release of IL-1β was a milestone in the elucidation of the pathogenesis of this disorder. IL-1β signaling is considered nowadays as the initiatory event that induces gouty inflammation and promotes the...
Paper Details
Title
Neutrophils, IL-1β, and gout: is there a link?
Published Date
Jan 24, 2013
Journal
Volume
35
Issue
4
Pages
501 - 512
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Notes
History