Plasma protein S residues 37–50 mediate its binding to factor Va and inhibition of blood coagulation
Abstract
Protein S (PS) is an anticoagulant plasma protein whose deficiency is associated with increased risk of venous thrombosis. PS directly inhibits thrombin generation by the blood coagulation pathways by several mechanisms, including by binding coagulation factors (F) Va and Xa. To identify PS sequences that mediate inhibition of FVa activity, antibodies and synthetic peptides based on PS sequence were prepared and employed in plasma coagulation...
Paper Details
Title
Plasma protein S residues 37–50 mediate its binding to factor Va and inhibition of blood coagulation
Published Date
Jan 1, 2013
Journal
Volume
110
Issue
08
Pages
275 - 282
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