Brachial-Ankle Pulse Wave Velocity and Microalbuminuria

Published on Jul 1, 2006in Hypertension Research2.941
· DOI :10.1291/HYPRES.29.469
Yoshio Nakamura12
Estimated H-index: 12
(Okayama University),
Hirofumi Makino98
Estimated H-index: 98
(Okayama University)
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Abstract
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Aims To test whether measuring hyperaemic changes in pulse wave velocity (PWV) could be used as a new method of assessing endothelial function for use in clinical practice. Methods and results Flow-mediated changes in vascular tone may be used to assess endothelial function and may be induced by distal hyperaemia, while endothelium-mediated changes in vascular tone can influence PWV. These three known principles were combined to provide and test a novel method of measuring endothelial function b...
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Hypertension is a well-known risk factor associated with high cardiovascular risk and kidney disease progression. Proteinuria commonly occurs in concert with hypertension in people with chronic kidney disease (CKD). The spectrum of albuminuria, from microalbuminaria (>30 but 300 mg per day) is associated with a linear increase in risk of cardiovascular events.1,2 Microalbuminuria correlates with the magnitude of C-reactive protein (CRP) elevations and has also been associated with a failure of n...
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Abstract The glomerular barrier is the kidney’s physical block to the unrestricted flow of molecules from the plasma into the urinary space. Its exquisite selectivity allows solutes and water in the glomerular capillaries to pass through but it prevents the bulk of plasma proteins, most notably albumin, froom crossing. Classically the barrier consists of three components: glomerular endothelium, glomerular basement membrane and glomerular epithelium (podocytes) with slit diaphragm. A lot of inve...
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Microalbuminuria is associated with impaired brachial artery, flow-mediated vasodilation in elderly individuals without and with diabetes: Further evidence for a link between microalbu- minuria and endothelial dysfunction—The Hoorn Study. Background. Extensive endothelial dysfunction (i.e., affect- ing many aspects of endothelial function) has been hypothe- sized to explain why microalbuminuria (MA) is associated with cardiovascular disease risk. However, it is not clear whether MA is specifical...
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Microalbuminuria is an early marker of renal damage and has been shown to predict future cardiovascular mortality and morbidity in patients with diabetes or hypertension, as well as in subjects in the general population. In this study, we investigated the hypothesis that the presence of microalbuminuria reflects the advancement of arterial stiffness by using a study group of 136 community residents who had no cardiovascular diseases except for hypertension and who were not taking any medications...
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