Three-month treatment with pioglitazone reduces circulating levels of thiobarbituric acid-reacting substances, a marker of reactive oxidative stress, without change in body mass index, in Japanese patients with type 2 diabetes

Patients with type 2 diabetes (T2DM) are at substantially higher risk of mortality, primarily from cardiovascular disease, than the general population [ [1] Roper N.A. Bilous R.W. Kelly W.F. Unwin N.C. Connolly V.M. Excess mortality in a population with diabetes and the impact of material deprivation: longitudinal, population based study. BMJ. 2001; 322: 1389-1393 Crossref PubMed Scopus (242) Google Scholar ]. The PROspective pioglitAzone...