Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
Abstract
Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism underlying these bothersome and dose-limiting adverse effects is unknown. We hypothesized that the transient receptor potential ankyrin 1 (TRPA1), a cation channel activated by oxidative stress and cold temperature, contributes to mechanical and cold hypersensitivity caused...
Paper Details
Title
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
Published Date
Jul 1, 2011
Journal
Volume
152
Issue
7
Pages
1621 - 1631
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