Opening the floodgates: proteomics and the integrin adhesome

Cell biologists studying cell adhesion have already figured out that cell–extracellular matrix connections, mediated by integrin receptors, are diverse and extremely complex structures. Dozens of adaptors — linking integrins with the cytoskeleton, and numerous enzymes and signaling proteins — regulating adhesion site dynamics, collectively referred to as the integrin adhesome, cooperate in mediating adhesion and activating specific signaling...