Immunogenic cell death and DAMPs in cancer therapy
Abstract
Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed calreticulin (CRT), secreted ATP and released high mobility group protein B1 (HMGB1). Most DAMPs...
Paper Details
Title
Immunogenic cell death and DAMPs in cancer therapy
Published Date
Nov 15, 2012
Journal
Volume
12
Issue
12
Pages
860 - 875
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Notes
History