Heme uptake across the outer membrane as revealed by crystal structures of the receptor–hemophore complex

Volume: 106, Issue: 4, Pages: 1045 - 1050
Published: Jan 27, 2009
Abstract
Gram-negative bacteria use specific heme uptake systems, relying on outer membrane receptors and excreted heme-binding proteins (hemophores) to scavenge and actively transport heme. To unravel the unknown molecular details involved, we present 3 structures of the Serratia marcescens receptor HasR in complex with its hemophore HasA. The transfer of heme over a distance of 9 A from its high-affinity site in HasA into a site of lower affinity in...
Paper Details
Title
Heme uptake across the outer membrane as revealed by crystal structures of the receptor–hemophore complex
Published Date
Jan 27, 2009
Volume
106
Issue
4
Pages
1045 - 1050
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