The blockade of immune checkpoints in cancer immunotherapy
Abstract
Among the most promising approaches to activating therapeutic antitumour immunity is the blockade of immune checkpoints. Immune checkpoints refer to a plethora of inhibitory pathways hardwired into the immune system that are crucial for maintaining self-tolerance and modulating the duration and amplitude of physiological immune responses in peripheral tissues in order to minimize collateral tissue damage. It is now clear that tumours co-opt...
Paper Details
Title
The blockade of immune checkpoints in cancer immunotherapy
Published Date
Mar 22, 2012
Journal
Volume
12
Issue
4
Pages
252 - 264
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Notes
History