MEK in cancer and cancer therapy
Abstract
The mitogen-activated extracellular signal-regulated kinase (MEK) pathway is one of the best-characterized kinase cascades in cancer cell biology. It is triggered by either growth factors or activating mutations of major oncogenic proteins in this pathway, the most common being Ras and Raf. Deregulation of this pathway is frequently observed and plays a central role in the carcinogenesis and maintenance of several cancers, including melanoma,...
Paper Details
Title
MEK in cancer and cancer therapy
Published Date
Feb 1, 2014
Journal
Volume
141
Issue
2
Pages
160 - 171
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Notes
History