TGF-β-Activated Kinase 1 Promotes Cell Cycle Arrest and Cell Survival of X-Ray Irradiated HeLa Cells Dependent on p21 Induction but Independent of NF-κB, p38 MAPK and ERK Phosphorylations

Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and without TAK1-knockdown were also examined after irradiation to elucidate the molecular mechanisms involved. After X-ray irradiation,...