bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Science56.90
Volume: 306, Issue: 5704, Pages: 2111 - 2115
Published: Dec 17, 2004
Abstract
Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop...
Paper Details
Title
bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Published Date
Dec 17, 2004
Journal
Volume
306
Issue
5704
Pages
2111 - 2115
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