Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats

Volume: 73, Issue: 1, Pages: 144 - 155
Published: May 1, 2015
Abstract
Substance P (SP) is known to stimulate angiogenesis, fibroblasts proliferation and expressions of cytokines and growth factors involved in wound healing. However, SP level reduces in dermis in diabetics and, hence, it was hypothesized that exogenously applied SP could be helpful in improving wound healing in diabetic rats. Excision skin wound was created on the back of diabetic rats and rats were divided into three groups i.e. (i) saline-, (ii)...
Paper Details
Title
Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats
Published Date
May 1, 2015
Journal
Volume
73
Issue
1
Pages
144 - 155
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