Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat
Abstract
In neonatal rats, superior colliculus (SC) ablation results in a massive and rapid increase in retinal ganglion cell (RGC) death that peaks about 24 h post‐lesion (PL). Naturally occurring cell death during normal development, and RGC death after axonal injury in neonatal and adult rats, has primarily been ascribed to apoptosis. Given that normal developmental cell death is reported to involve caspase 3 activation, and blocking caspase activity...
Paper Details
Title
Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat
Published Date
Jan 1, 2005
Volume
21
Issue
1
Pages
33 - 45
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