Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease
Abstract
Alexander disease is a progressive, usually fatal neurological disorder defined by the widespread and abundant presence in astrocytes of protein aggregates called Rosenthal fibers. The disease most often occurs in infants younger than 2 years and has been labeled a leukodystrophy because of an accompanying severe myelin deficit in the frontal lobes. Later onset forms have also been recognized based on the presence of abundant Rosenthal fibers....
Paper Details
Title
Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease
Published Date
Feb 24, 2005
Journal
Volume
57
Issue
3
Pages
310 - 326
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Notes
History