Topically applied substance P enhanced healing of open excision wound in rats

Significant social and financial burden due to wounds need newer drugs/formulations to speed up the healing process. Substance P (SP), a neuropeptide, is associated with release of various cytokines and growth factors from inflammatory, epithelial and endothelial cells. In the present study, temporal effects of topically applied SP (10−7 M in normal saline) were evaluated in the modulation of various cytokines and growth factors that participate...