Topography-Induced Cell Adhesion to Acr-sP(EO-stat-PO) Hydrogels: The Role of Protein Adsorption

Volume: 11, Issue: 10, Pages: 1378 - 1386
Published: Jul 22, 2011
Abstract
Topographic surface patterning of intrinsically non-adhesive P(EO-stat-PO)-based hydrogels can lead to the adhesion and spreading of fibroblasts. Explanations for this unexpected behavior are discussed, particularly with regard to non-specific protein adsorption from the serum-supplemented culture medium. The presence of serum proteins is shown to be essential for adhesion. Adsorption of plasma and ECM proteins (Fibronectin (FN) and Vitronectin...
Paper Details
Title
Topography-Induced Cell Adhesion to Acr-sP(EO-stat-PO) Hydrogels: The Role of Protein Adsorption
Published Date
Jul 22, 2011
Volume
11
Issue
10
Pages
1378 - 1386
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