Tumour stem cells and drug resistance

Published on Apr 1, 2005in Nature Reviews Cancer53.03
· DOI :10.1038/NRC1590
Michael Dean116
Estimated H-index: 116
,
Tito Fojo85
Estimated H-index: 85
,
Susan E. Bates110
Estimated H-index: 110
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Abstract
The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies.
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