Tumour stem cells and drug resistance
Abstract
The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem...
Paper Details
Title
Tumour stem cells and drug resistance
Published Date
Apr 1, 2005
Journal
Volume
5
Issue
4
Pages
275 - 284
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Notes
History