Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
Abstract
The in vitro analysis of intestinal epithelium has been hampered by a lack of suitable culture systems. Here we describe robust long-term methodology for small and large intestinal culture, incorporating an air-liquid interface and underlying stromal elements. These cultures showed prolonged intestinal epithelial expansion as sphere-like organoids with proliferation and multilineage differentiation. The Wnt growth factor family positively...
Paper Details
Title
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
Published Date
Apr 27, 2009
Journal
Volume
15
Issue
6
Pages
701 - 706
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Notes
History