A Potent Gelatinase Inhibitor with Anti‐Tumor‐Invasive Activity and its Metabolic Disposition

Metastatic tumors lead to more than 90% fatality. Despite the importance of invasiveness of tumors to poor disease outcome, no anti‐invasive compounds have been commercialized. We describe herein the synthesis and evaluation of 4‐(4‐(thiiranylmethylsulfonyl)phenoxy)‐phenyl methanesulfonate (compound 2 ) as a potent and selective inhibitor of gelatinases (matrix metalloproteinases‐2 and ‐9), two enzymes implicated in invasiveness of tumors. It...