Rapid action of estradiol in primate GnRH neurons: The role of estrogen receptor alpha and estrogen receptor beta
Abstract
Estrogens play a pivotal role in the control of female reproductive function. Recent studies using primate GnRH neurons derived from embryonic nasal placode indicate that 17β-estradiol (E(2)) causes a rapid stimulatory action. E(2) (1nM) stimulates firing activity and intracellular calcium ([Ca(2+)](i)) oscillations of primate GnRH neurons within a few min. E(2) also stimulates GnRH release within 10min. However, the classical estrogen...
Paper Details
Title
Rapid action of estradiol in primate GnRH neurons: The role of estrogen receptor alpha and estrogen receptor beta
Published Date
Feb 1, 2011
Journal
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