Smoking cessation at the clinical onset of chronic pancreatitis and risk of pancreatic calcifications.

Published on Nov 1, 2007in Pancreas2.92
· DOI :10.1097/MPA.0B013E31812E965E
Giorgio Talamini39
Estimated H-index: 39
(University of Verona),
Claudio Bassi110
Estimated H-index: 110
(University of Verona)
+ 7 AuthorsItalo Vantini36
Estimated H-index: 36
(University of Verona)
Objective: Cigarette smoking is associated with a higher risk of developing chronic pancreatitis (CP) and increases the likelihood of developing pancreatic calcifications. The aim of this study was to know whether smoking cessation modifies the course of the disease. Methods: Patients with CP who had been followed up for more than 6 years from clinical onset and who had not developed calcifications after 5 years were analyzed. We studied smokers, never-smokers, and patients who had given up smoking within 5 years. For actuarial analysis, the sixth year was considered as time 0. Results: Of the 360 patients, there were 43 women and 317 men (88.1%) with a mean age of 38.7 years. The median follow-up was 19.0 years. Chronic pancreatitis was alcohol-associated in 255 patients, hereditary in 10, obstructive in 54, and idiopathic in 41. There were 317 smokers (88.1%) and 259 alcohol drinkers (71.9%). At the end of the follow-up, 212 patients (59.8%) developed calcifications. Concerning the risk of calcifications, never-smokers and ex-smokers had similar actuarial curves, and these were significantly different from the curve for smokers (P Conclusions: Smoking cessation in the first years from the clinical onset of CP reduces the risk of developing pancreatic calcifications.
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