May the Reduction of Exposure to Specific Sensitizers Be an Alternative to Work Cessation in Occupational Asthma? Results from a Follow-Up Study

Published on Feb 2, 2012in International Archives of Allergy and Immunology2.749
· DOI :10.1159/000327550
Pierluigi Paggiaro7
Estimated H-index: 7
Sources
Abstract
Background: Few data are reported on the effects of a reduction of exposure to specific sensitizers in occupational asthma (OA). The objective of this study was to evaluate the clin
📖 Papers frequently viewed together
19989.41Chest
5 Authors (Luca Perfetti, ..., Jean-Luc Malo)
References25
Newest
#1Bernadette R. Gochuico (NIH: National Institutes of Health)H-Index: 33
#2Thomas C. Markello (NIH: National Institutes of Health)H-Index: 33
Last. William A. Gahl (NIH: National Institutes of Health)H-Index: 103
view all 6 authors...
Source
#1Susan M. Tarlo (U of T: University of Toronto)H-Index: 59
#2John R. Balmes (UCSF: University of California, San Francisco)H-Index: 84
Last. Julia Heitzer (American College of Chest Physicians)H-Index: 2
view all 17 authors...
Background A previous American College of Chest Physicians Consensus Statement on asthma in the workplace was published in 1995. The current Consensus Statement updates the previous one based on additional research that has been published since then, including findings relevant to preventive measures and work-exacerbated asthma (WEA). Methods A panel of experts, including allergists, pulmonologists, and occupational medicine physicians, was convened to develop this Consensus Document on the diag...
Source
#1George Rachiotis (Imperial College London)H-Index: 19
#2Rashna SavaniH-Index: 1
Last. Paul CullinanH-Index: 69
view all 6 authors...
Background: Patients with occupational asthma, and their medical advisers, need valid information about the prognosis of their disease. Methods: A systematic review of the published literature on the symptomatic and functional outcomes of occupational asthma was carried out after avoidance of exposure to the causative agent. Through a full search of electronic and bibliographic sources, original studies documenting complete recovery from asthma (n = 39,1681 patients) or improvement in non-specif...
Source
#1Frédéric GirardH-Index: 2
#2Simone ChaboillezH-Index: 12
Last. Catherine Lemière (UdeM: Université de Montréal)H-Index: 59
view all 9 authors...
Monitoring airway inflammation by means of induced sputum cell counts seems to improve the management of asthma. We sought to assess whether such monitoring at the end of periods at and away from work combined with the monitoring of PEF could improve the diagnosis of occupational asthma. We enrolled subjects suspected of having occupational asthma. Serial monitoring of PEF was performed during 2 weeks at and away from work. At the end of each period, induced sputum was collected. Specific inhala...
Source
Recent data suggest that responsiveness to methacholine continues to improve 2 and more years after cessation of exposure to agents causing occupational asthma (OA). The goal of this study was to characterize further the curve of improvement to methacholine responsiveness in subjects with OA. Eighty subjects with confirmed OA who had at least two assessments of a provocative concentration of histamine causing a 20% drop in FEV1 (PC20) and were seen for at least 2 years after cessation of exposur...
Source
Subjects with occupational asthma (OA) generally present asthma symptoms and airway hyperresponsiveness after cessation of exposure. We hypothesized that they are also left with airway inflammation. We assessed 133 subjects with OA at a mean interval of 8.7 years (0.5–20.8 years) after cessation of exposure by questionnaire, airway caliber, and responsiveness to methacholine. Satisfactory samples of induced sputum were obtained from 98 subjects. We defined three groups of subjects: (1) cured: no...
Source
#1A. Marabini (University of Perugia)H-Index: 11
#2Andrea Siracusa (University of Perugia)H-Index: 26
Last. Giuseppe Abbritti (University of Perugia)H-Index: 17
view all 5 authors...
Study objective To evaluate the effect of treatment with beclomethasone dipropionate (500 μg bid) and salmeterol (50 μg bid) on lung function and respiratory symptoms in 20 subjects with occupational asthma (OA) still exposed to the work environment cause of their disease. Methods At enrollment and every 6 months for 3 years, respiratory symptom score (from 0 [no symptoms] to 2 [moderate-to-severe symptoms]), spirometry, methacholine challenge, peak expiratory flow (PEF) variability, and the use...
Source
#1Moscato GH-Index: 1
#2Jean-Luc Malo (UdeM: Université de Montréal)H-Index: 67
Last. Bernstein DH-Index: 1
view all 3 authors...
Diagnosing occupational asthma is still a challenge because it is based on a stepwise approach in which the depth of investigative means may vary depending on resources. The authors herewith review the existing investigative means from the approach of outlining controversies and queries. There is no validated clinical questionnaire for diagnosing occupational asthma. Immunological investigation is limited by the lack of standardised extracts for skin-prick testing and specific immunoglobulin E a...
Source
#1Michele Padoan (UNIPD: University of Padua)H-Index: 2
#2Valeria PozzatoH-Index: 2
Last. C. E. MappH-Index: 57
view all 10 authors...
Eighty-seven cases of occupational asthma induced by toluene diisocyanate (TDI) were diagnosed by an inhalation challenge with TDI and methacholine. After an average follow-up interval of 11 yrs, all subjects were re-examined. Of the 87 subjects examined, 13 (15%) had remained in the same job, 44 (50.5%) had been removed from exposure for 10 yrs. The proportion of subjects who experienced symptoms of asthma and those who were hyperresponsive to methacholine was significantly lower. Of the patien...
Source
#6Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
Abstract The diagnosis of occupational asthma is usually performed in epidemiology using a combination of symptoms and bronchial hyperresponsiveness, while in a clinical setting the ‘gold standard' for the diagnosis of occupational asthma is the specific bronchial challenge test in the laboratory. The aim of this study was to detect new cases of flour-induced occupational asthma (OA) in a group of workers exposed to grain and/or flour dust, by means of a step-by-step approach, as used in a clini...
Source
Cited By8
Newest
#1Paul K. Henneberger (NIOSH: National Institute for Occupational Safety and Health)H-Index: 34
#2Jenil Patel (University of Arkansas for Medical Sciences)H-Index: 8
Last. Stefania Curti (UNIBO: University of Bologna)H-Index: 18
view all 7 authors...
BACKGROUND The objective was to update the 2011 Cochrane systematic review on the effectiveness of workplace interventions for the treatment of occupational asthma. METHODS A systematic review was conducted with the selection of articles and reports through 2019. The quality of extracted data was evaluated, and meta-analyses were conducted using techniques recommended by the Cochrane Handbook for Systematic Reviews of Interventions. RESULTS Data were extracted from 26 nonrandomized controlled be...
Source
#1Katja RadonH-Index: 49
#2Dennis NowakH-Index: 70
Last. Franziska RuëffH-Index: 48
view all 4 authors...
Background: One-third of all young persons entering the work force have a history of atopic disease. Occupationally induced allergy and asthma generally arise in the first few months on the job, while pre-existing symptoms tend to worsen. Young persons with a history of an atopic disease should receive evidence-based advice before choosing a career. Methods: We systematically searched PubMed for cohort studies investigating the new onset of asthma, rhinitis, or hand eczema among job trainees fro...
Source
#1D TaliniH-Index: 13
#2Federica Novelli (UniPi: University of Pisa)H-Index: 11
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 13 authors...
Objective To evaluate the potential determinants of forced expiratory volume in 1 s (FEV1) decline in workers with occupational asthma (OA) still exposed to the causative agent. We hypothesised that sputum eosinophilia might be a predictor of poor asthma outcome after diagnosis. Setting, design and participants In a specialistic clinical centre of the University Hospital of Pisa, we studied 39 participants (28 M, 11 F) diagnosed as having OA, routinely followed up between 1990 and 2009. They wer...
Source
#1Xavier Muñoz (Ciber)H-Index: 33
#2M. ViladrichH-Index: 2
Last. Javier SastreH-Index: 56
view all 9 authors...
Summary Aim To assess the evolution of occupational asthma (OA) depending on whether the patient avoids or continues with exposure to the offending agent. Methods Study in patients diagnosed with OA using a specific inhalation challenge. Patients underwent the following examinations on the same day: clinical interview, physical examination, forced spirometry, methacholine test and determination of total IgE. Clinical improvement, deterioration or no change were defined according to the changes s...
Source
#1Daniela Pelclova (Charles University in Prague)H-Index: 29
#2Zdenka Fenclova (Charles University in Prague)H-Index: 21
Last. Petr KačerH-Index: 27
view all 11 authors...
Objectives To search for optimal markers in the exhaled breath condensate (EBC), plasma and urine that would reflect the activity/severity of occupational asthma (OA) after the withdrawal from the exposure to the allergen.
Source
#1Federica NovelliH-Index: 11
#2Elena BacciH-Index: 27
view all 11 authors...
#1Edgardo JaresH-Index: 14
#2Carlos E. Baena-Cagnani (CUA: The Catholic University of America)H-Index: 38
Last. R. Maximiliano GómezH-Index: 3
view all 3 authors...
Work-related asthma (WRA) includes patients with sensitizer- and/or irritant-induced asthma in the workplace, as well as patients with preexisting asthma that is worsened by work factors. WRA is underdiagnosed; thus, the diagnosis is critical to prevent disease progression and its potential for morbidity and mortality. The interview is the first diagnostic tool to be used by physicians, and the question, “Does asthma improve away from work?” is of the highest sensitivity. However, history can sh...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.